DENVER -- Offensive lineman Darrion Weems left Saturday's game with 13:29 to go in the second quarter with a possible concussion.

He was helped off the field by two trainers during the Broncos' contest against the 49ers.

Weems has been taking first-team reps since Ty Sambrailo injured his arm during training camp.

Rookie Connor McGovern replaced Weems at right guard on Saturday night.

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Linebacker Corey Nelson appeared to injure his right wrist with 11:23 to go in the second quarter of Saturday's game.

A trainer stabilized Nelson's arm as they helped the third-year player off the field.

Nelson was hurt on a run play up the middle. He had been taking reps as Todd Davis' backup at the inside linebacker spot. 

He is questionable to return.

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UPDATE:Weems and Nelson have both been ruled out for the remainder of Saturday's game with a concussion and wrist injury, respectively.