Five Key Matchups: Broncos vs. Bills

Chris Harris Jr. picked off his first pass of the season in Week 2 vs. the Cowboys, and he'll look to add to his collection against the Bills. This week's target of the dangerous "No-Fly Zone"? Jordan Matthews, who came to Buffalo in the offseason to provide Taylor with a deep threat. He's already recorded a 47-yard reception in the early stages of this season, and he is likely to be the Bills' first option on the outside. Matthews has hauled in five passes for 91 yards so far, but if Harris and Aqib Talib can slow him down, the Bills' passing attack will be hard-pressed to find any sustainable success against the Broncos.

In his third career game, rookie tackle Dion Dawkins will face perhaps the best edge rusher he'll see all season. Filling in for Cordy Glenn, Dawkins will find himself battling Von Miller, who recorded two sacks last week against Dallas. Miller could be in for another big day if Dawkins — with help — can't slow him down. Should Miller burst past Dawkins on several occasions to take down Tyrod Taylor, the Broncos' defense will almost certainly turn in a big performance, and Miller will be back on pace for 20-plus sacks.

Along a dangerous Buffalo front seven, linebacker Lorenzo Alexander may pose the biggest threat. Even without Marcell Dareus up front to help clear lanes, Alexander is still capable of rushing through nearly any gap, and he had more than a little success in 2016. After a 12.5-sack season, Alexander was selected to the second Pro Bowl of his career at the age of 33. He'll look to continue that success in his second season in Buffalo, and it will be up to players like Ron Leary to stop him. Leary, a free-agent pickup from Dallas, has proved to be a great addition along the Broncos' offensive line. A dynamic run blocker, Leary will also be challenged to help deal with a dangerous Alexander, who will be looking to get to Trevor Siemian.

Plenty has been made this week about LeSean McCoy's prowess as a runner — and for good reason. In Week 1, McCoy rushed for 110 yards on 22 carries as he got off to another great start. Though he was bottled up by the Panthers and only turned in 12 carries for 9 yards, there's no doubting his ability. The five-time Pro Bowler and two-time First-Team All-Pro has been among the best at his position for years. Still, he poses just as much of a challenge out of the backfield as a receiver. He's averaged nearly 8 yards per reception over the course of his career, and that could be a dangerous option for the Bills. Linebackers Todd Davis and Brandon Marshall must find a way to cover the dangerous McCoy, or the Broncos could find themselves in a repeat situation of last year's game against the Falcons, in which Tevin Coleman tore up the interior of the defense.

Through two weeks, Virgil Green has reeled in three catches for 55 yards, including a 44-yard fourth-quarter reception against the Chargers in Week 1. In all, the Broncos' tight ends have been a pleasant surprise in Offensive Coordinator Mike McCoy's system, and the team will look for that trend to continue in Buffalo. This week, Green will find himself matched up against fifth-year safety Jordan Poyer, an Oregon State product with 14 tackles on the season. Poyer has also broken up five passes in the early season and recorded an interception. The Bills' free safety is also dangerous in the backfield — he has two sacks this season — but his real work Sunday will come against Green.